ESCRT-I Inhibition Protects against NMDAR Hypofunction and Restores Synaptic Homeostasis in a Cellular Model of Schizophrenia
Mohamed Fouad Shalaby, Vincenzo Prato, Jacobo Elíes, Nikita L. Gamper, Samantha Louise McLean, Sriharsha Kantamneni
The paper shows that inhibiting ESCRT-I prevents NMDAR hypofunction and restores synaptic homeostasis in a schizophrenia model caused by PCP exposure.
bioRxiv · Sep 13, 2026 · PreprintNeuroscience