Nikita L. Gamper

This study identifies Esyt1 as a scaffold organizing ER-PM nanodomains that regulate inflammatory pain signaling through Ca2+-dependent interactions.

The paper shows that inhibiting ESCRT-I prevents NMDAR hypofunction and restores synaptic homeostasis in a schizophrenia model caused by PCP exposure.

The paper identifies peptides based on the autoinhibitory XY linker of PLCβ isoforms that inhibit PLCβ activity and reduce inflammation and pain in a mouse model.

This study identifies DBI as a glial messenger that modulates mechanosensation through GABAA receptor interaction in DRG, offering a new therapeutic target for pain management.

The paper demonstrates that dorsal root ganglia (DRG) filter nociceptive signals through axonal t-junctions, with GABAergic cells enhancing this filtering and reducing pain hypersensitivity in models of inflammation and neuropathy.

This study shows that REST deficiency leads to increased Kv7.4 channels in auditory neurons and hair cells, causing progressive hearing loss, which can be reversed by Kv7.4 inhibition.

This study identifies JPH4 as essential for ER-PM junction formation and inflammatory pain through SOCE and Ca2+ signaling in rat DRG neurons.

This study identifies GM-CSF's role in bone cancer pain by upregulating voltage-gated sodium channels via Jak2/Stat3 signaling in DRG neurons.