Author

Thanh Thanh L. Nguyen

Mayo ClinicORCID 0000-0002-2281-6540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:fine-mapping· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Abhijeet S. BarathiD· 2 shared Duan LiuiD· 2 shared Huanyao GaoiD· 2 shared Jeong‐Heon LeeiD· 2 shared Liewei WangiD· 2 shared Lixuan WeiiD· 2 shared Richard M. WeinshilboumiD· 2 shared Tamás ÖrdögiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Abhijeet S. BarathORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis

Abhijeet S. Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily C. Dale, Flavia Goche, Thanh Thanh L. Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A. Jewanee, Anthony D. Umpierre, Dale B. Bosco, Koichiro Haruwaka, , Long‐Jun Wu

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

JCI Insight · Jun 21, 2026Peer-reviewedNeuroscience

Functional dissection of complex and molecular trait variants at single nucleotide resolution

Layla Siraj, Rodrigo I. Castro, Hannah B. Dewey, Susan Kales, John C. Butts, Thanh Thanh L. Nguyen, Masahiro Kanai, Daniel Berenzy, Kousuke Mouri, Qingbo S. Wang, Petko P. Fiziev, Kristin Tsuo, Zachary Ryan McCaw, Sager J. Gosai, François Aguet, , Ryan Tewhey

This study functionally characterizes 221,412 trait-associated variants using MPRA in 5 cell types, identifying 12,025 regulatory variants and revealing widespread epistasis and non-TF mechanisms.

Nature · Feb 25, 2026Peer-reviewedGenetics

Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

Thanh Thanh L. Nguyen, Huanyao Gao, Duan Liu, Trudy Janice Philips, Zhenqing Ye, Jeong‐Heon Lee, Geng‐Xian Shi, Kaleigh M. Copenhaver, Lingxin Zhang, Lixuan Wei, Jia Yu, Huan Zhang, Abhijeet S. Barath, Maggie Luong, Cheng Zhang, , Richard M. Weinshilboum

The paper shows glucocorticoid exposure reveals the function of non-coding genetic variants linked to disease risk by influencing gene expression in relevant biological processes.

Nucleic Acids Research · Nov 11, 2022Peer-reviewedGenomics

Glucocorticoids Mediate Transcriptome-wide Alternative Polyadenylation: Mechanisms and Functional Implications

Thanh Thanh L. Nguyen, Duan Liu, Huanyao Gao, Zhenqing Ye, Jeong‐Heon Lee, Lixuan Wei, Jia Yu, Lingxin Zhang, Liewei Wang, Tamás Ördög, Richard M. Weinshilboum

This study shows glucocorticoids regulate alternative polyadenylation in human B-lymphoblastoid cells, affecting gene function and immune-related pathways.

bioRxiv · Mar 30, 2022 · PreprintGenomics