Hemakumar M. Reddy

The paper identifies piRNAs from Y-chromosome gene families that regulate autosomal gene expression in mouse testis through homology to gene UTRs and genomic regions.

This study identifies a Y-chromosome noncoding RNA, Pirmy, that regulates autosomal gene expression via piRNAs in mouse testis, contributing to male fertility and speciation.

The paper identifies a piRNA cluster on the mouse Y chromosome and shows that transcripts from multicopy gene families encode both piRNAs and proteins.

Transcriptome sequencing improves the diagnostic rate for Mendelian disease in patients for whom genetic analysis has not returned a diagnosis.

The paper develops a pooled sequencing method to detect meiotic drivers in Drosophila and identifies a candidate driver in a centromere-linked region with an 8% increased transmission frequency.