Vidu Garg

This study shows that human cardiomyocytes with trisomy 21 are more susceptible to SARS-CoV-2 infection and show an amplified immune response compared to euploid controls.

This study shows that endocardial HDAC3 is essential for myocardial trabeculation by regulating TGFβ3 expression through miR-129-5p repression in mice.

Natian and Ryabhatta are R Shiny apps that provide a GUI for creating, analyzing, and visualizing single-cell transcriptomic data using the Seurat pipeline, improving accessibility and reducing errors.

This study uses single-cell RNA-sequencing to identify how maternal hyperglycemia affects cardiac cell-type specific gene regulation, increasing the risk of congenital heart defects.

The paper identifies a novel recessive frameshift variant in MYL2 causing severe infantile-onset HCM and shows molecular differences between recessive and dominant MYL2 variants.