Human cardiomyocytes with trisomy 21 exhibit heightened susceptibility and immunological response to SARS-CoV-2 infection
Matthew Alonzo, KC Mahesh, Cankun Wang, Jerry Wang, Jakob Bering, Qin Ma, Vidu Garg, Mark E. Peeples, Mingtao Zhao
This study shows that human cardiomyocytes with trisomy 21 are more susceptible to SARS-CoV-2 infection and show an amplified immune response compared to euploid controls.
bioRxiv · Jun 22, 2026 · PreprintCell Biology