Antagonizing the serotonin receptor HTR2B drives antigen-specific cytotoxic T-cell responses and controls colorectal cancer growth.
Surojit Karmakar, Girdhari Lal
This study shows that HTR2B antagonism suppresses colon tumor growth and metastasis by enhancing cytotoxic T-cell responses and reducing PD-L1 expression.
bioRxiv · Feb 26, 2025 · PreprintImmunology