Author

Kristine L. Witt

National Institute of Environmental Health SciencesORCID 0000-0002-3827-6884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:human· 1 Organism:rat· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Charles C. ValentineiD· 2 shared Elizabeth K. SchmidtiD· 2 shared Fang Yin LoiD· 2 shared Jesse J. SalkiD· 2 shared Leslie RecioiD· 2 shared Miriam V. RivasiD· 2 shared Stephanie L. Smith‐RoeiD· 2 shared Andrew WilliamsiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Charles C. ValentineORCID

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2 papers

Recent·Most cited

GenomicsMutation Research/Genetic Toxicology and Environmental MutagenesisPeer-reviewedAug 2, 2023

Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats

Stephanie L. Smith‐Roe, Cheryl A. Hobbs, Victoria Hull…·Kristine L. Witt

This paper evaluates a DuplexSeq-based mutagenesis assay in ENU-exposed rats, showing early detection of mutations and reproducible results across tissues and labs.

23 citations

ratwhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 22, 2023

Error-corrected Duplex Sequencing enables direct detection and quantification of mutations in human TK6 cells with remarkable inter-laboratory consistency

Eunnara Cho, Carol D. Swartz, Andrew Williams…·Carole Lyn Yauk

This study demonstrates that error-corrected Duplex Sequencing reliably detects and quantifies mutations in human TK6 cells across different laboratories and time points.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky