Andrew Williams

The paper introduces a statistical framework to analyze mutation spectra in error-corrected sequencing data, showing it maintains Type I error control and greater power than existing methods.

This study assesses the mutagenic and clastogenic effects of benzo[b]fluoranthene in mice using Duplex Sequencing and the micronucleus assay, showing dose-dependent increases in mutation frequency and cancer-related mutation spectra.

This study uses Duplex Sequencing to assess mutation frequencies and spectra in MutaMouse bone marrow after procarbazine exposure, showing its advantages over conventional assays.

This study demonstrates that error-corrected Duplex Sequencing reliably detects and quantifies mutations in human TK6 cells across different laboratories and time points.

This study evaluates gene expression profiles from FFPE and fresh-frozen mouse liver tissues using various methods, finding ribo-depletion RNA-seq provides the best results for FFPE samples.