Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
Victoria L. Wyckelsma, Tomas Venckūnas, Peter J. Houweling, Maja Schlittler, Volker Martin Lauschke, Chrystal F. Tiong, Harrison D. Wood, Niklas Ivarsson, Henrikas Paulauskas, Nerijus Eimantas, Daniel C. Andersson, Kathryn N. North, Marius Brazaitis, Håkan Westerblad
The paper shows that absence of α-actinin-3 in humans improves cold resilience through changes in skeletal muscle thermogenesis and myosin heavy chain composition.
The American Journal of Human Genetics · Feb 17, 2021Peer-reviewedGenetics