Volker Martin Lauschke

This study identifies NNMT as a regulator linking inflammation to epigenetic changes in liver fibrosis, showing its role in cytokine-induced transcriptional and fibrotic responses.

This study identifies molecular changes in early MASLD progression in obesity through transcriptomic and metabolomic analyses, revealing distinct metabolic pathways and novel gene targets for liver fibrosis.

This study investigates FFA2R allosterism across cell models, showing pathway-selective modulation and highlighting Ca2+ mobilization and ROS as therapeutic readouts.

The paper identifies placental cell-type-specific transcriptional responses to maternal obesity and fetal growth using single-nucleus RNAseq and microfluidic organoids.

This study identifies miR-210 as a protective factor against hepatic steatosis by inhibiting CIDEC expression in MASLD.

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

This study shows that TAK-981, a SUMO inhibitor targeting SAE1, reduces RMS cell growth and enhances chemotherapy effectiveness without increasing radiosensitivity.

This study shows that activating estrogen receptors in male mice reduces HFD-induced liver steatosis by modulating gene expression and TEAD1, suggesting TEAD1 inhibition as a therapeutic strategy for NAFLD.

Scellseg is a cell segmentation tool that uses pre-training and contrastive fine-tuning, outperforming existing methods on three datasets with minimal training data.

The paper shows that absence of α-actinin-3 in humans improves cold resilience through changes in skeletal muscle thermogenesis and myosin heavy chain composition.