Author

Alessandra Esposito

Scuola Superiore MeridionaleORCID 0000-0002-3838-7242Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea BallabioiD· 1 shared Gennaro NapolitanoiD· 1 shared James H. HurleyiD· 1 shared Zhicheng CuiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Andrea BallabioORCID

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1 paper

Recent·Most cited

BiochemistryNaturePeer-reviewedSep 17, 2025

Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1

Zhicheng Cui, Alessandra Esposito, Gennaro Napolitano…·James H. Hurley

This study determines the cryo-EM structure of mTORC1 on the lysosomal membrane, showing how growth factor and nutrient signals integrate through three-step recruitment and membrane engagement.

49 citationstop 1%

cryo-EMexperimental assay

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