Author

Gennaro Napolitano

Federico II University HospitalORCID 0000-0002-8615-4654Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alessandra EspositoiD· 1 shared Andrea BallabioiD· 1 shared Dimitrios MougiakakosiD· 1 shared Federica SoràiD· 1 shared Francesca SaccoiD· 1 shared Gessica Minnella· 1 shared Giorgia MassacciiD· 1 shared James H. HurleyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Alessandra EspositoORCID

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2 papers

Recent·Most cited

BiochemistryNaturePeer-reviewedSep 17, 2025

Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1

Zhicheng Cui, Alessandra Esposito, Gennaro Napolitano…·James H. Hurley

This study determines the cryo-EM structure of mTORC1 on the lysosomal membrane, showing how growth factor and nutrient signals integrate through three-step recruitment and membrane engagement.

49 citationstop 1%

cryo-EMexperimental assay

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Systems BiologybioRxivPreprintJan 8, 2025

Phosphoproteomics reveals novel BCR::ABL1-independent mechanisms of resistance in chronic myeloid leukemia

Valeria Bica, Veronica Venafra, Giorgia Massacci…·Francesca Sacco

The paper identifies BCR::ABL1-independent survival mechanisms in CML using phosphoproteomics and computational analysis, highlighting FLT3 as a therapeutic target for TKI-resistant cases.

1 citation

humanproteomics

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