Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.
Prem Prakash, Purva Khodke, Muthukumar Balasubramaniam, Benem-Orom Davids, Thomas Hollis, Jamaine S. Davis, Jui Pandhare, Bajarang Vasant Kumbhar, Chandravanu Dash
This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.
Journal of Biological Chemistry · Jun 3, 2024Peer-reviewedBiochemistry