Author

Prem Prakash

Meharry Medical CollegeORCID 0000-0001-6507-7875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:DNA methylation· 1 Approach:statistical model· 1

Frequent Co-Authors

Chandravanu DashiD· 3 shared Christopher AikeniD· 2 shared Jui PandhareiD· 2 shared Muthukumar BalasubramaniamiD· 2 shared Rajasree ChakrabortyiD· 2 shared Adrian PadroniD· 1 shared Alan EngelmaniD· 1 shared Bajarang Vasant KumbhariD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

Chandravanu DashORCID

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3 papers

Recent·Most cited

BiochemistryJournal of VirologyPeer-reviewedApr 9, 2025

CPSF6 Promotes HIV-1 Preintegration Complex Function

Evan Chaudhuri, Sooin Jang, Rajasree Chakraborty…·Chandravanu Dash

This study shows CPSF6 promotes HIV-1 preintegration complex function by enhancing viral DNA integration into gene-dense regions and restoring integration activity when added back to mutant cells.

7 citations

humanexperimental assay

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedOct 31, 2024

Cyclophilin A Facilitates HIV-1 DNA Integration

Adrian Padron, Richa Dwivedi, Rajasree Chakraborty…·Chandravanu Dash

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.

9 citations

humanexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedJun 3, 2024

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

Prem Prakash, Purva Khodke, Muthukumar Balasubramaniam…·Chandravanu Dash

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

2 citations

humanDNA methylation

𝕏 PostBluesky