Author

Paul A. Hamel

University of TorontoORCID 0000-0002-3844-8850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Connie T. Y. Xie· 2 shared John B. VincentiD· 2 shared Paul W. FranklandiD· 2 shared Stephen F. PastoreiD· 2 shared Roya Derwish· 1 shared Sierra C. El-masri· 1 shared Tahir MuhammadiD· 1 shared Tereza BLÁHOVÁ· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Connie T. Y. Xie

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2 papers

Recent·Most cited

Molecular BiologyBiological Psychiatry Global Open SciencePeer-reviewedMar 22, 2025

Autism-associated PTCHD1 missense variants bind to the SNARE-associated protein, SNAPIN, but exhibit impaired subcellular trafficking

Stephen F. Pastore, Connie T. Y. Xie, Roya Derwish…·John B. Vincent

The paper identifies a novel interaction between PTCHD1 and SNAPIN and shows that some missense variants impair subcellular trafficking without affecting binding.

2 citations

humanproteomics

𝕏 PostBluesky

Molecular BiologyCellsPeer-reviewedJan 21, 2024

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

Connie T. Y. Xie, Stephen F. Pastore, John B. Vincent…·Paul A. Hamel

This paper investigates how nonsynonymous mutations in PTCHD1 affect protein stability and N-glycosylation, showing disrupted glycosylation processing but normal localization and interaction with SAP102.

8 citations

humanproteomics

𝕏 PostBluesky