Stephen F. Pastore

Identification of Antiviral Drug Candidates Against Monkeypox DNA Polymerase and Profilin-like Protein A42R Utilizing an In-Silico Approach

This study identifies potential antiviral drug candidates against MPXV DNA polymerase and A42R protein using in-silico methods, highlighting compounds with high docking scores and stable ligand-protein complexes.

Autism-associated PTCHD1 missense variants bind to the SNARE-associated protein, SNAPIN, but exhibit impaired subcellular trafficking

The paper identifies a novel interaction between PTCHD1 and SNAPIN and shows that some missense variants impair subcellular trafficking without affecting binding.

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

This paper investigates how nonsynonymous mutations in PTCHD1 affect protein stability and N-glycosylation, showing disrupted glycosylation processing but normal localization and interaction with SAP102.

Autism spectrum disorder trios from consanguineous populations are enriched for rare biallelic variants, identifying 32 new candidate genes