Daniel B. McClatchy

Quantitation of Spatial Proteoforms in Alzheimer's Disease

The paper quantifies spatial proteoforms in Alzheimer's disease by analyzing subcellular protein localization and identifies key pathways disrupted in disease progression.

ESCRT-0 regulates AMPA receptor currents and Ca2+- dependent signaling

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.

In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network.

The paper maps protein-protein interactions of schizophrenia risk factors in rodent brains, revealing an interconnected disease network and showing how PCP perturbations alter these interactions.

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

The paper identifies Emerin as an activity-induced protein that gates neuronal plasticity by inhibiting protein synthesis and altering dendritic spine morphology.

PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response

The paper shows that PrPC ligands in human neurons trigger PLCγ1 signaling and an Arc/Arg3.1 response, indicating neuronal hyperactivity in prion disease.

Acid cleavable biotin-alkyne improves sensitivity for direct detection of biotin labeled peptides in BONCAT analysis.

This study compares cleavable and uncleavable biotin-alkyne labels in BONCAT analysis, finding that cleavable labels improve protein identification and quantification.

Do perineuronal nets stabilize the engram of a synaptic circuit?

The paper investigates whether perineuronal nets (PNNs) stabilize synaptic circuits and engram formation through high-resolution imaging and experimental approaches.

Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

In vivo Protein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer's Disease

The paper uses in vivo protein footprinting to study dynamic conformational changes in the proteome across multiple tissues in Alzheimer's disease progression, finding that structural changes precede expression changes in key pathways.

A Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation

This study uses proteomic techniques to profile newly synthesized proteins in AD transgenic mice, revealing age-dependent changes and dysregulated vesicle transport networks prior to Aβ accumulation.

Role of the Visual Experience-Dependent Nascent Proteome in Neuronal Plasticity

The paper identifies novel proteins synthesized in response to visual experience in Xenopus tectal neurons and shows their role in structural and behavioral plasticity.

Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimers disease like pathology

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.

Exosomes regulate Neurogenesis and Circuit Assembly in a Model of Rett Syndrome

This study shows that exosomes from control neural cultures can rescue neural development defects in Rett Syndrome by influencing neuron number, apoptosis, and synaptic function.