Author

Alicia Plourde

University of GuelphORCID 0000-0002-3874-2806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1

Frequent Co-Authors

Siavash VahidiiD· 2 shared Adwaith B. UdayiD· 1 shared Jacquelyn C. Ogata-BeaniD· 1 shared Natalie ZeytuniiD· 1 shared Taylor J. B. ForresteriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBiochemistry

Siavash VahidiORCID

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2 papers

Recent·Most cited

Structural basis of substrate recognition for proteasome degradation by prokaryotic ubiquitin-like protein ligase PafA

Alicia Plourde, Adwaith B. Uday, Taylor J. B. Forrester, Natalie Zeytuni, Siavash Vahidi

The paper determines the structural basis of substrate recognition by PafA, showing that broad specificity arises from dynamic, geometrically compatible interactions rather than sequence-specific binding.

bioRxiv · Apr 11, 2026 · PreprintBiochemistry

Probing the structural heterogeneity of Pup ligase PafA using H/D exchange mass spectrometry

Alicia Plourde, Jacquelyn C. Ogata-Bean, Siavash Vahidi

This study uses HDX-MS to investigate the oligomeric states and conformational dynamics of PafA, revealing its monomeric and dimeric forms and how nucleotide binding affects its structure and function.

Journal of Biological Chemistry · Mar 22, 2025Peer-reviewedBiochemistry