Natalie Zeytuni

Structural tuning of native type V fimbriae shapes mechanical specialization in Porphyromonas gingivalis

This study determines the structural and mechanical differences between two type V fimbriae in P. gingivalis, showing how structural tuning leads to distinct mechanical properties.

A Sensory Pathway that Controls Bacterial Zorbing

The paper identifies a sensory pathway in Flavobacterium johnsoniae that controls the transition between swarming and zorbing, linking environmental sensing to collective behavior and spatial organization.

Resolving hidden stoichiometries in Bacterial proteasome activator (Bpa)-substrate complexes by cryo-EM and charge detection mass spectrometry

This study uses cryo-EM and charge detection mass spectrometry to determine the stoichiometry and structure of Bpa-substrate complexes in Mtb, revealing an undecameric apo form and a Bpa12:HspR2 complex.

Structural and mechanistic basis of ubiquitous bacterial kinase signaling identifies PorX as a noncanonical substrate in Porphyromonas gingivalis

This study determines the structure and mechanism of UbK1, a bacterial kinase in P. gingivalis, identifies PorX as a noncanonical substrate, and shows UbK1's role extends beyond canonical secretion pathways.

Structural basis of substrate recognition for proteasome degradation by prokaryotic ubiquitin-like protein ligase PafA

The paper determines the structural basis of substrate recognition by PafA, showing that broad specificity arises from dynamic, geometrically compatible interactions rather than sequence-specific binding.

Mechanism of allosteric activation in human mitochondrial ClpP protease

This study reveals the activation mechanism of human mitochondrial ClpP protease through structures showing how inhibitors induce an allosteric transition to the active state, with implications for cancer therapy.

Structural basis for allosteric regulation of the proteasome core particle

The paper presents the first high-resolution structure of Mycobacterium tuberculosis 20S core particle in an inactive state, revealing the structural basis for allosteric regulation.

Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.