Cancer BiologybioRxivPreprint
NOX4 prevents the recruitment of PAX8 and NKX2.1 to chromatin in BRAF-mutated thyroid cancer cells.
Mickaëlle Radom, Camille Buffet, Juliana Cazarin…·Corinne Dupuy
The paper shows that NOX4-generated ROS repress NIS in BRAFV600E-mutated thyroid cancer cells by blocking PAX8 and NKX2.1 chromatin binding through DNA damage and epigenetic mechanisms.
DOI 10.1101/2025.04.14.647724