NOX4 prevents the recruitment of PAX8 and NKX2.1 to chromatin in BRAF-mutated thyroid cancer cells.
Mickaëlle Radom, Camille Buffet, Juliana Cazarin, Marylin Harinquet, Caroline Coelho de Faria, Floriane Brayé, Catline Nobre, Marine Aglave, Yasmina Mesloub, Thibault Dayris, Nathalie M Droin, Karine Godefroy, Mohamed Amine Bani, Abir Al Ghuzlan, Sophie Leboulleux, , Corinne Dupuy
The paper shows that NOX4-generated ROS repress NIS in BRAFV600E-mutated thyroid cancer cells by blocking PAX8 and NKX2.1 chromatin binding through DNA damage and epigenetic mechanisms.
bioRxiv · Apr 14, 2025 · PreprintCancer Biology