Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites
Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony Philip Jackson
This study uses molecular modeling and simulations to show that N-linked glycans on Nav channel alpha-subunits may block beta-subunit Ig-domain binding and influence channel clustering.
The Journal of General Physiology · Nov 26, 2024Peer-reviewedBiochemistry