Christopher A. Beaudoin

HANSEN: An Integrated Structural and Functional Proteome Resource for Structure-Guided Drug Discovery in Mycobacterium leprae

Web resource offering predicted monomeric and oligomeric structures for 1,603 M. leprae proteins, with pockets, epitope scores, essentiality and a target priority ranking, plus a nanopore resistance-calling module.

Reduced entropy of subthalamic beta bursts predicts freezing of gait in Parkinsons disease

The paper identifies reduced entropy of subthalamic beta bursts as a predictor of freezing of gait in Parkinson's disease.

Structural implications of glycosylation on the voltage-gated sodium channel β3-subunit

This paper investigates the structural impact of glycosylation on the β3-subunit of voltage-gated sodium channels using glycan profiling and molecular dynamics simulations.

Pathological cortico-STN beta coupling in Parkinson's disease is confined to beta bursts

The paper examines cortico-STN beta coupling in Parkinson's disease, finding it is confined to beta bursts rather than sustained during non-burst periods.

Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity

The paper assesses similarity between drug targets and human microbiome metaproteomes to identify potential off-target effects and pharmacological promiscuity.

Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites

This study uses molecular modeling and simulations to show that N-linked glycans on Nav channel alpha-subunits may block beta-subunit Ig-domain binding and influence channel clustering.

Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA

This study identifies potential protein-coding regions in negative-sense RNA intermediates of SARS-CoV-2 using bioinformatics and structural analysis.

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

The paper identifies potential structural mimicry of coronavirus spike receptor-binding motifs by human and non-human proteins using structural bioinformatics and docking simulations.

Producing Polished Prokaryotic Pangenomes with the Panaroo Pipeline

Panaroo's graph-based pangenome clustering uses gene adjacency across genomes to correct annotation errors, shrinking spurious accessory genomes and enlarging core genomes in simulated and real bacteria.