Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy
Osheen Sahay, Ganesh Kumar Barik, Samya Dey, Sehbanul Islam, Debasish Paul, Praneeta Pradip Bhavsar, Somsubhra Nath, Srikanth Rapole, Manas Kumar Santra
This study shows that FBXO31-mediated γH2AX foci formation is essential for DNA repair pathways and that its loss sensitizes breast cancer to chemotherapy.
bioRxiv · Jun 3, 2024 · PreprintCancer Biology