Author

Amy Louise Brittle

University of SheffieldORCID 0000-0002-3911-0181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

A L Dunne· 1 shared A. Andreou· 1 shared A. Ansari· 1 shared A. Carter· 1 shared A. Cartwright· 1 shared A. Hadonou· 1 shared A. Joshi· 1 shared A. Kolozi· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

A L Dunne

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2 papers

Recent·Most cited

Genetic & Genomic MedicineGenetics in MedicinePeer-reviewedSep 5, 2025

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

Sophie Allen, Charlie F Rowlands, Samantha Butler…·Catarina Olimpio

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

3 citations

humanwhole-exome sequencing

𝕏 PostBluesky

Developmental BiologybioRxivPreprintApr 17, 2020

Identification of functionally-distinct macrophage subpopulations regulated by efferocytosis in Drosophila

Jonathon Alexis Coates, Amy Louise Brittle, Emma Louise Armitage…·Iwan Robert Evans

The paper identifies functionally distinct plasmatocyte subpopulations in Drosophila regulated by efferocytosis and shows how their behavior and abundance can be modulated.

2 citations

Drosophilaexperimental assay

𝕏 PostBluesky