Dongmei Wang

This study uses scRNA-seq to show Dsg1 coordinates cell proliferation and actin dynamics to drive epidermal morphogenesis through a Dsg1-Nck1-N-WASP axis.

The paper creates a multimodal atlas of human scalp tissue, revealing cell states, lineage organization, and disease-specific perturbations in hair loss conditions.

This study shows that miR-200 inhibits SOX9 and cell cycle progression to block sebaceous gland fate specification in hair follicles.

This study shows that MOF-mediated H4K16ac is essential for mitochondrial and ciliary functions in mammalian skin development, with loss of MOF causing severe developmental defects.

This study shows that miR-205 modulates the mechanical properties of hair follicle stem cells and progenitors to promote hair regeneration.

This paper introduces scHolography, a deep learning method to reconstruct 3D tissue organization from single-cell transcriptome data, enabling analysis of cell-cell interactions and spatial heterogeneity.