Rui Yi

Desmoglein-1 coordinates cell proliferation and actin dynamics to promote epidermal morphogenesis.

This study uses scRNA-seq to show Dsg1 coordinates cell proliferation and actin dynamics to drive epidermal morphogenesis through a Dsg1-Nck1-N-WASP axis.

Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ

The paper creates a multimodal atlas of human scalp tissue, revealing cell states, lineage organization, and disease-specific perturbations in hair loss conditions.

Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification

This study shows that miR-200 inhibits SOX9 and cell cycle progression to block sebaceous gland fate specification in hair follicles.

Compartmentalization of mRNA and Translation by Desmosomes

The paper identifies desmosomal proteins as essential for cortical compartmentalization of translation and mRNA, revealing dynamic regulation of the cortical translatome in response to wounding.

MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

This study shows that MOF-mediated H4K16ac is essential for mitochondrial and ciliary functions in mammalian skin development, with loss of MOF causing severe developmental defects.

MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

This study shows that miR-205 modulates the mechanical properties of hair follicle stem cells and progenitors to promote hair regeneration.

Reconstruction of 3-dimensional tissue organization at the single-cell resolution

This paper introduces scHolography, a deep learning method to reconstruct 3D tissue organization from single-cell transcriptome data, enabling analysis of cell-cell interactions and spatial heterogeneity.

Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome

This study identifies miRNA targets using a direct capture method, showing miRNAs regulate thousands of transcripts and reveal pathways involved in cancer and signaling.