BiochemistryNature CommunicationsPeer-reviewed
Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure
Eric M. Lynch, Yao Lu, Jin‐Ho Park…·E. Hesper Rego
This study shows that Mycobacterium tuberculosis CTP synthase forms unique filaments that stabilize enzyme activity and resist inhibition, with mutations affecting filament formation under positive selection in clinical isolates.
3 citations