Author

Giacomo Domenici

Instituto de Biologia Experimental e TecnológicaORCID 0000-0002-3947-5930Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:machine learning (classical)· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Catarina BritoiD· 3 shared Gonçalo TrindadeiD· 2 shared Miguel PintoiD· 2 shared Nádia DuarteiD· 2 shared Ana Sofia CoroadinhaiD· 1 shared Angelina S. PalmaiD· 1 shared Catarina FreitasiD· 1 shared Francisca Arez· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

Catarina BritoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 6, 2026

CRISPR-Cas9 Editing of Myeloid Lectins Reveals Target-Dependent Transcriptional Remodeling in Tumor-Associated Macrophages

Gonçalo Trindade, Miguel Pinto, Giacomo Domenici…·Catarina Brito

This study uses CRISPR-Cas9 to perturb myeloid lectins in macrophages, revealing target-specific transcriptional changes and immunometabolic reprogramming in tumor-associated macrophages.

DOI 10.64898/2026.10.02.756241

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintSep 8, 2026

Myeloid Lectin Profiling Identifies SYK as a Targetable Signaling Node for Remodeling Immunosuppressive Tumor-Associated Macrophages in Breast Cancer

Gonçalo Trindade, Giacomo Domenici, Miguel Pinto…·Catarina Brito

DOI 10.64898/2026.09.04.749378

humanbulk RNA-seq

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ImmunologyScientific ReportsPeer-reviewedDec 6, 2025

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

Isabella Ramella Gal, Francisca Arez, Inês P. Correia…·Catarina Brito

This study develops a 3D co-culture model of human hepatocytes and Kupffer-like cells to investigate innate immune responses to rAAV vectors.

4 citations

humanexperimental assay

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