Catarina Brito

This study uses CRISPR-Cas9 to perturb myeloid lectins in macrophages, revealing target-specific transcriptional changes and immunometabolic reprogramming in tumor-associated macrophages.

This study develops a 3D co-culture model of human hepatocytes and Kupffer-like cells to investigate innate immune responses to rAAV vectors.

This study develops a perfusion bioreactor system to co-culture hiPSC-derived erythromyeloid progenitors with neurospheres, mimicking microglial features in CNS development.

The paper develops a 3D human CNS model from hiPSCs to study immune responses to rAAV gene therapy, finding that iMGL-iNSpheroids show mild, transient inflammation to rAAV9.

This paper develops a 3D human retinal organoid model to study early diabetic retinopathy and identifies molecular and cellular features associated with the disease.