Aleš Cvekl

The paper identifies abundant RNA-binding proteins in mouse lenses and characterizes their interactions with crystallin and β-actin mRNAs using proteomic, transcriptomic, and imaging techniques.

This study establishes a mouse model of Crybb3 loss-of-function and identifies proteomic changes in the lens, including downregulation of multiple proteins and altered transcription factor activation.

The paper shows that rRNA transcription continues in differentiating lens fiber cells until nuclear degradation, supporting translational mechanisms for crystallin protein production.

This study investigates how the lens placode modulates extracellular matrix formation during early eye development in chicken and mouse models, showing a role for BMP signaling and Timp2 in ECM remodeling.