Author

Jianming Hu

Pennsylvania State UniversityORCID 0000-0002-3967-2133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Adam ZlotnickiD· 1 shared Daniel D. LoebiD· 1 shared Emad TajkhorshidiD· 1 shared Haitao LiuiD· 1 shared Ji XiiD· 1 shared Joseph Che‐Yen WangiD· 1 shared Karolyn Pionek· 1 shared Katie CulhaneiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Adam ZlotnickORCID

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2 papers

Recent·Most cited

DNA synthesis inside the hepatitis B virus creates a high-energy spool

Nora Gibes, Katie Culhane, Haitao Liu, Ji Xi, Karolyn Pionek, Smita Nair, Daniel D. Loeb, Jianming Hu, Adam Zlotnick, Joseph Che‐Yen Wang

The paper determines the structures of mature HBV and Duck HBV, revealing that DNA forms a spool within the capsid that interacts with interior charges and creates a metastable state for genome uncoating.

bioRxiv · Jan 23, 2026 · PreprintMicrobiology

A Spatial Whole-Cell Model for Hepatitis B Viral Infection and Drug Interactions

Zhaleh Ghaemi, Oluwadara Nafiu, Emad Tajkhorshid, Martin Gruebele, Jianming Hu

This paper develops a whole-cell computational model of HBV infection and drug interactions to predict infection pathways and optimal drug dosing.

bioRxiv · Jun 1, 2022 · PreprintSystems Biology