Joseph Che‐Yen Wang

Programmable Self-Assembly of RNA Nanostructures with >100 Unique Components

This paper introduces a method to create complex RNA nanostructures with over 100 unique components using dsRNA bricks, overcoming limitations of RNA scalability and stability.

Extracellular Vesicles Mediate Activation and Trafficking of Splenic Immune Cells to the Heart Post-Myocardial Infarction

This study shows that extracellular vesicles from the heart after myocardial infarction drive immune cell trafficking to the heart, and inhibiting these vesicles reduces inflammation and improves cardiac function.

DNA synthesis inside the hepatitis B virus creates a high-energy spool

The paper determines the structures of mature HBV and Duck HBV, revealing that DNA forms a spool within the capsid that interacts with interior charges and creates a metastable state for genome uncoating.

The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants

Pre-existing and acquired CD4 T cell deficiency facilitates outgrowth of Ab-escape viral variants during persistent infection.

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

This study investigates how the ratio of nucleic acid to SARS-CoV-2 N-protein affects liquid-liquid phase separation (LLPS) and finds that a 1:1 ratio maximizes condensate formation.

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2

This paper reports the structure of Arabidopsis RDR2 and shows how it initiates transcription from RNA templates displaced from RNA-DNA hybrids.