Roman M. Dickey

Robust cellular transformations of PET deconstruction products by import of glycol esters

This study demonstrates that E. coli can efficiently uptake and convert PET deconstruction products into upcycled reduction products with high yields.

Air-driven aldehyde synthesis in engineered bacteria via gene deletion and aryl-alcohol oxidase profiling

This paper engineers Escherichia coli to oxidize non-native alcohols using high-expression aryl-alcohol oxidases, enabling air-driven aldehyde synthesis.

Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids in engineered bacteria

This paper presents a modular bacterial system for biosynthesizing and incorporating phenylalanine derivatives into proteins using achiral building blocks, reducing reliance on complex chemical synthesis.

Reductive amination cascades in cell-free and resting whole cell formats for valorization of lignin deconstruction products

The paper develops enzyme cascades for converting lignin-derived carboxylic acids into amines using cell-free and whole-cell biocatalysis, demonstrating new substrates and recyclable systems.

Genome engineering allows selective conversions of terephthalaldehyde to multiple valorized products in bacterial cells

The paper demonstrates that genome engineering of E. coli improves TPAL retention and enables its conversion to valuable products like para-xylylenediamine.

Combinatorial gene inactivation of aldehyde dehydrogenases mitigates aldehyde oxidation catalyzed by resting cells of E. coli RARE strains

The paper demonstrates that combinatorial gene inactivation of aldehyde dehydrogenases in E. coli reduces aldehyde oxidation in resting cells, improving aldehyde bioconversion.

Reductive Enzyme Cascades for Valorization of PET Deconstruction Products

This paper demonstrates biocatalytic enzyme cascades that convert PET deconstruction products into valuable mono-amine and diamine building blocks.