X G Sun

A gene-augmentation framework for selected early-stage autosomal recessive retinitis pigmentosa genotypes

The paper identifies tractable genes for gene-augmentation therapy in autosomal recessive retinitis pigmentosa using AAV vectors and evaluates PDE6B in animal models.

Myeloid Suclg2 deficiency attenuates aortic dissection by reshaping succinate-associated macrophage remodelling

This study shows that myeloid Suclg2 deficiency reduces aortic dissection by altering macrophage metabolism and systemic metabolic profiles.