Yunlu Xue

The paper identifies tractable genes for gene-augmentation therapy in autosomal recessive retinitis pigmentosa using AAV vectors and evaluates PDE6B in animal models.

This study shows neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD mice by lowering BACE1 and other proteins in these structures.

This study designs cell type-specific AAV promoters using deep learning, outperforming rational approaches in mouse retinal cells and showing promise for human applications.

This study identifies FAT3's role in bipolar cells for high-frequency light response in mouse retina, showing its necessity for synaptic localization of GRIK1.

This study investigates the effects of Txnip alleles and related proteins on cone survival in a retinitis pigmentosa mouse model, finding that specific Txnip variants and interactions with HSP90AB1 improve cone survival.

This study shows that enhancing CD47-SIRPα signaling protects cones in retinal degeneration models by promoting survival and preserving vision.