Xin Chen

The paper identifies tractable genes for gene-augmentation therapy in autosomal recessive retinitis pigmentosa using AAV vectors and evaluates PDE6B in animal models.

This study isolates and characterizes a novel virus, vB_PshM_Y4, showing it is not detectable by high-throughput sequencing and belongs to an unknown viral family.

This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.

The paper shows that fibronectin-dependent tissue stiffness controls durotaxis and cell rearrangements through a phase transition model in mouse limb bud mesoderm.

This study differentiates human hindbrain neuroepithelial stem cells into cerebellar granule neurons in vitro, recapitulating key progenitor states and showing SHH's role in lineage specification and maturation.

Decoder-seq is a spatial RNA sequencing method that provides high-resolution, cost-effective, and sensitive spatial transcriptomic analysis, revealing detailed spatial gene expression patterns in mouse hippocampus and renal cancer.

This paper optimizes WGCNA's Topology Overlap Matrix calculation using OpenMP and SQLite for multithreading, reducing computation time on SMP systems.

GeneQC estimates the reliability of gene expression levels from RNA-Seq data by analyzing mapping uncertainty, improving downstream analysis validity.