PathologybioRxivPreprint
Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development
Jiajie Hu, Dongsheng Yu, Dongmei Wu…·Hongwei Ouyang
This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.