BioengineeringJournal of Biological EngineeringPeer-reviewed
Staged heavy-chain filtering enables Fab discovery from combinatorially intractable library spaces
Youngju Kim, Hayoung Kwon, Jisu Hong…·Chang-Han Lee
This paper introduces a staged approach to Fab discovery by sequentially enriching heavy-chain variants and remating them with light-chain repertoires to overcome combinatorial complexity in antibody library screening.
DOI 10.1186/s13036-026-00794-y