Frits Koning

This study maps CD4 T cell plasticity and spatial organization in IBD tissues, revealing regulatory-Th17 plasticity and interactions with CD8 cells.

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

The paper develops a 37-color spectral flow cytometry panel to analyze T cell phenotypes and cytokine expression in human intestinal samples, with applications in inflammatory bowel disease research.

The paper identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease by systematically prioritizing candidate genes in disease loci using multiple computational methods.

The paper introduces a Linear Discriminant Analysis classifier for predicting cell types in mass cytometry data, showing comparable performance to state-of-the-art methods and scalability to large datasets.

The paper introduces HSNE for analyzing mass cytometry data, revealing rare cell types and overcoming t-SNE's scalability limitations.