Author

Janine E. Melsen

Leiden University Medical CenterORCID 0000-0001-5322-7194Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aharon G. FreudiD· 1 shared Aline ZbindeniD· 1 shared Amir HorowitziD· 1 shared André F. RendeiroiD· 1 shared Ansel P. NaliniD· 1 shared Arjan C. LankesteriD· 1 shared Benjamin IzariD· 1 shared Bethany L. Mundy-BosseiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

Aharon G. FreudORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 22, 2026

Mapping human natural killer cell development in tonsil

Everardo Hegewisch-Solloa, Janine E. Melsen, Ansel P. Nalin…·Emily Margaret Mace

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

DOI 10.64898/2026.05.13.722762

humanspatial transcriptomics

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ImmunologybioRxivPreprintMay 26, 2026

Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets

Martijn Cordes, Erik B. van den Akker, Janine E. Melsen…·Kirsten Canté-Barrett

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

DOI 10.64898/2026.05.21.725517

humanscRNA-seq

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ImmunologybioRxivPreprintAug 30, 2024

Immunophenotyping of T cells combined with Vβ antibodies identifies long lasting CMV related T cell expansions with a consistent TIGIT and PD-1 phenotype

Monique M. van Ostaijen-ten Dam, Marco W. Schilham, Arjan C. Lankester, Janine E. Melsen

The paper develops a flow cytometry method to analyze T cell receptor Vβ and phenotype simultaneously, identifying long-lasting CMV-related T cell expansions with consistent TIGIT and PD-1 expression.

DOI 10.1101/2024.08.30.610465

humanflow cytometry

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