Erik B. van den Akker

Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrow

This paper uses spatial multi-omics to identify immunosuppressive interactions between AML, macrophages, and T cells in bone marrow, highlighting the Galectin-9 - CD44/TIM-3 axis as a therapeutic target.

Human CEBPA-N AML exhibits enhanced engraftment and a C/EBPα-p30-driven leukemic stem cell program

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

This study identifies rare genetic variants in the IIS/mTOR pathway in long-lived humans and shows they have shared functional effects on lifespan-related traits in mice.

Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

This study examines how a lifestyle intervention affects the blood transcriptomic and metabolomic responses to a nutrient challenge in elderly individuals.

The AccelerAge framework: A new statistical approach to predict biological age based on time-to-event data

The paper introduces the AccelerAge framework, a statistical method for predicting biological age using time-to-event data, and evaluates it against existing predictors.

Mapping of the gene network that regulates glycan clock of ageing

The paper identifies 16 genomic loci associated with IgG galactosylation through GWAS and validates three genes using CRISPR/dCas9 in an in vitro system.

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

The paper identifies two rare variants in the MAPK/ERK pathway from long-lived families and shows they affect signaling and metabolism differently in mouse embryonic stem cells.

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

Metabolic predictors of phenotypic traits can replace and complement measured clinical variables in transcriptome-wide association studies

This study evaluates metabolic predictors as alternatives to clinical variables in TWAS, finding they yield similar results and can complement incomplete phenotypic data.

Lifestyle-intervention-induced reduction of abdominal fat is reflected by a decreased circulating glycerol level and an increased HDL diameter

This study shows that lifestyle interventions reducing abdominal fat are linked to lower circulating glycerol and higher HDL diameter, independent of BMI or overall weight loss.

High-throughput data-driven analysis of myofiber composition reveals muscle-specific disease and age-associated patterns

The paper develops a high-throughput method to analyze myofiber composition and identifies age- and muscle-specific patterns and disease-related changes.