Jihye Park

Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors

This study identifies conserved neuronal-like and secretory programs in GEP-NETs and links them to spatial microenvironmental niches and metastatic potential.

Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer

This study identifies tumor-myeloid crosstalk as a driver of cisplatin resistance in bladder cancer and proposes PARP14 inhibition as a therapeutic strategy.

Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

Evaluating agentic AI for biological discovery in autonomous and copilot settings

This study evaluates agentic AI's ability to support biological discovery in autonomous and human-AI copilot settings using multi-omic cancer datasets.

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel

The paper identifies genomic features associated with response or resistance to Gem/Doce in BCG-unresponsive NMIBC using whole-exome sequencing and phylogenetic analysis.

Genomic, Clinical, and Spatial Predictors of Durable Response to BRAF/MEK Inhibition in BRAF-Mutant Melanoma

Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers

The paper identifies polygenic risk factors and rare variants in unexplained familial cancers using whole genome sequencing and family history data.

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.

Evaluation of single-cell RNA profiling technologies using FFPE, fresh, and frozen ccRCC tumor specimens

The paper compares single-cell RNA profiling technologies using different sample types to assess their performance in tumor specimens.

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

The paper analyzes multiomic data from primary and metastatic esophageal adenocarcinoma tumors to identify cell states and their spatial interactions, linking them to clinical outcomes.

Immune Spatial Organization Predicts Metastasis Risk in Aggressive Localized Prostate Cancer

The paper identifies immune spatial organization as a biomarker predicting metastasis risk in high-grade prostate cancer using computational pathology and H&E slides.

Integrative Analysis of Germline Rare Variants in Clear and Non-Clear Cell Renal Cell Carcinoma

This study identifies germline rare variants associated with clear and non-clear cell RCC, accounting for population stratification, and finds distinct risk patterns and somatic associations.

Mutational footprint of platinum chemotherapy in a secondary thyroid cancer

This paper reports a case where platinum chemotherapy exposure was linked to the development of aggressive thyroid cancer through mutational signatures and genomic analysis.

Biologically informed deep neural network for prostate cancer classification and discovery

This paper introduces a biologically informed deep learning model for prostate cancer classification and identifies molecular drivers of treatment resistance.

Transcriptional mediators of treatment resistance in lethal prostate cancer

This study identifies transcriptional states in mCRPC that mediate treatment resistance, including AR splicing heterogeneity, TGF-β signaling, and immune infiltration patterns.