Salvador Casaní-Galdón

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

The paper investigates the YMC phase transitions by integrating metabolic, chromatin, and transcriptional data, finding that metabolite accumulation mediates the shift between HOC and LOC phases.

This paper develops a CRISPRi approach using truncated guides to screen multiple transcription factor binding sites, showing they can disrupt enhancer activity and repress transcription factor binding.

The paper identifies 10 PTEN enhancers and proposes a new model of enhancer organization that includes spatial separation of functional and structural elements.