Pawan Kumar Dhar

Uncovering organizing principles of protein-protein interaction networks

This study examines protein-protein interaction networks, validating power laws, identifying network compression during evolution, and exploring hub connectivity patterns.

Repurposing the dark genome. IV - noncoding proteins

The paper explores the possibility of generating functional noncoding proteins from non-coding RNA sequences using computational analysis.

Harnessing Escherichia coli Dark Genome to Produce Anti-Alzheimer Peptides

The paper identifies two peptides from E. coli DNA sequences that inhibit BACE1, reducing its levels by 86.7% in vitro.

Repurposing The Dark Genome. III - Intronic Proteins

This study computationally translates full-length introns to explore their potential to encode functional proteins, extending previous work on intergenic sequences in E. coli.

ClearX9-Stem™: an efficient, affordable & sustainable stem cell culture medium for biotech and cell-cultivated meat industries

The paper introduces ClearX9-Stem, a serum-free stem cell culture medium that replaces fetal bovine serum, supporting chicken embryonic fibroblast growth without animal slaughter.

Repurposing the dark genome. II - Reverse Proteins

The paper explores reverse proteins generated by reading natural protein-coding sequences in the -1 frame, revealing new functional possibilities in E. coli, S. cerevisiae, and D. melanogaster.

Repurposing the dark genome. I - Antisense Proteins

This paper explores the potential to generate functional proteins from non-expressing genomic sequences in E. coli by studying antisense DNA sequences.

Discovery of tREP-18, a novel class of tRNA encoded peptide with potent leishmanicidal activity

The paper reports a novel tRNA-derived peptide, tREP-18, with potent anti-leishmanial activity against L. donovani and PKDL isolates.

HYPO: A database of hypothetical human proteins

The paper introduces an updated database of hypothetical human proteins with enhanced features and functionalities.