Author

Marlene Dalgaard

Copenhagen University HospitalORCID 0000-0002-4036-6408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Research Focus:polygenic risk· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Organism:zebrafish· 1

Frequent Co-Authors

Alejandro SifrimiD· 1 shared Ali Amin Al OlamaiD· 1 shared Alison P. KleiniD· 1 shared Amanda B. SpurdleiD· 1 shared Amber N. HursoniD· 1 shared Andrew BerchuckiD· 1 shared Anna WilsdoniD· 1 shared Beatrice S. MeliniD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Alejandro SifrimORCID

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2 papers

Recent·Most cited

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

Yan Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F. Easton, Roger Laughlin Milne, Jacques Simard, Per N Hall, Kyriaki Michailidou, Joe Dennis, Marjanka K. Schmidt, Jenny C. Chang-Claude, Puya Gharahkhani, David C. Whiteman, Peter T. Campbell, , Colon Cancer Family Registry (CCFR)

This study assesses polygenicity and risk prediction using common variants across 14 cancers, finding varying numbers of susceptibility variants and risk score effectiveness.

Nature Communications · Jul 3, 2020Peer-reviewedGenetics

Systems genetics analysis identify calcium signalling defects as novel cause of congenital heart disease

José M. G. Izarzugaza, Sabrina Gade Ellesøe, Canan Doğanlı, Natasja Spring Ehlers, Marlene Dalgaard, Enrique Audain, Gregor Dombrowsky, Alejandro Sifrim, Anna Wilsdon, Bernard Thienpont, Jeroen Breckpot, Marc H. M. L. Gewillig, Competence Network for Congenital Heart Defects, Germany, J. David Brook, Marc‐Phillip Hitz, , Søren Brunak

The paper identifies calcium signalling defects as a novel cause of congenital heart disease through whole exome sequencing and functional validation in zebrafish.

bioRxiv · Dec 11, 2019 · PreprintGenetics