Andrew Berchuck

This study shows ascites protects ovarian cancer cells from ferroptosis and promotes peritoneal metastasis by modulating lipid metabolism and iron homeostasis.

This study investigates how aging affects ovarian cancer progression by analyzing gene expression, lipid metabolism, and immune cell changes in rat models, finding that aged adipose microenvironment promotes tumor growth.

This study improves transcriptome-wide association studies by integrating pleiotropy-guided methods with GWAS data to identify new cancer susceptibility genes.

This study assesses polygenicity and risk prediction using common variants across 14 cancers, finding varying numbers of susceptibility variants and risk score effectiveness.

This study combines genome-wide association data from four cancers to identify shared and novel genetic associations and pleiotropic effects.

This study identifies germline genetic variants influencing somatic mutation patterns in 2,642 cancer genomes across 39 cancer types.

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.

This study quantifies genetic correlations between six solid cancers and other diseases using GWAS data, finding shared heritability and functional enrichment in regulatory regions.