Author

Canan Doğanlı

University of CopenhagenORCID 0000-0002-5230-0801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Organism:zebrafish· 3 Research Focus:differential expression· 2 Assay:whole-exome sequencing· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Lars Allan LarseniD· 4 shared Søren T. ChristenseniD· 3 shared Daniel A. BairdiD· 2 shared Enrique AudainiD· 2 shared Lotte Bang PederseniD· 2 shared Marc‐Phillip HitziD· 2 shared Muhammad FarooqiD· 2 shared Oskar Kaaber ThomseniD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersDevelopmental Biology

Lars Allan LarsenORCID

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4 papers

Recent·Most cited

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development

Canan Doğanlı, Oskar Kaaber Thomsen, Daniel A. Baird, Yeasmeen Ali, Menachem Viktor Sarusie, Enrique Audain, Line Jeanett Jessen, Pauline Munck Truelsen, Johanne Bay Mogensen, Maria Schrøder Holm, Kateřina Apolínová, Lorenzo Buttò, Maria Diamanti, Jindřiška Leischner Fialová, Emma M. Wade, , Lars Allan Larsen

The paper identifies TAK1's role in heart development through genetic analysis and shows its activation at the primary cilium via TGFB/BMP signaling.

PLoS Biology · Aug 4, 2026Peer-reviewedDevelopmental Biology

Rare homozygous cilia gene variants identified in consanguineous congenital heart disease patients

Daniel A. Baird, Hira Mubeen, Canan Doğanlı, Jasmijn B. Miltenburg, Oskar Kaaber Thomsen, Zafar Ali, Tahir Naveed, Asif ur Rehman, Shahid Mahmood Baig, Søren T. Christensen, Muhammad Farooq, Lars Allan Larsen

The paper identifies rare homozygous variants in cilia genes associated with congenital heart defects in consanguineous Pakistani patients.

Human Genetics · Sep 30, 2024Peer-reviewedGenetic & Genomic Medicine

Systems genetics analysis identify calcium signalling defects as novel cause of congenital heart disease

José M. G. Izarzugaza, Sabrina Gade Ellesøe, Canan Doğanlı, Natasja Spring Ehlers, Marlene Dalgaard, Enrique Audain, Gregor Dombrowsky, Alejandro Sifrim, Anna Wilsdon, Bernard Thienpont, Jeroen Breckpot, Marc H. M. L. Gewillig, Competence Network for Congenital Heart Defects, Germany, J. David Brook, Marc‐Phillip Hitz, , Søren Brunak

The paper identifies calcium signalling defects as a novel cause of congenital heart disease through whole exome sequencing and functional validation in zebrafish.

bioRxiv · Dec 11, 2019 · PreprintGenetics

RRP7A links primary microcephaly to radial glial cells and dysfunction of ribosomal biogenesis, neurogenesis and ciliary resorption

Muhammad Farooq, Louise Lindbæk, Nicolai Krogh, Canan Doğanlı, Cecilie Keller, Maren Mönnich, Srinivasan Sakthivel, Yuan Mang, Ambrin Fatima, Vivi Søgaard Andersen, Muhammad Sajid Hussain, Hans Eiberg, Lars Hestbjerg Hansen, Klaus Wilbrandt Kjaer, Jay Gopalakrishnan, , Lars Allan Larsen

This study identifies a mutation in RRP7A linked to primary microcephaly, showing its role in neurogenesis, ribosomal biogenesis, and ciliary resorption in neural stem cells.

bioRxiv · Oct 10, 2019 · PreprintNeuroscience