Cancer BiologyChemical SciencePeer-reviewed
Sequence-defined oligophosphoesters for selective inhibition of the KRAS G12D/RAF1 interaction
Bini Claringbold, Steven Vance, Alexandra R. Paul…·Christopher J. Serpell
The paper develops sequence-defined oligophosphoesters to inhibit the KRAS G12D/RAF1 interaction, achieving low IC50 values and selectivity for the mutant form.